huagongshe.com
HRID132872

反应详情

EQUATION

反应方程式

HRID 132872 的结构方程式

REACTANTS

反应物

2
结构：NN
HCID9321

Hydrazine

H4N2

结构：CC1C(=O)C(C(O)C=O)CCN1C(=O)OC(C)(C)C
HCID86604215

未命名化合物

PRODUCTS

生成物

1
结构：CC1c2nnccc2CCN1C(=O)OC(C)(C)C
HCID69192961

1,1-Dimethylethyl 5,8-dihydro-8-methylpyrido[3,4-c]pyridazine-7(6H)-carboxylate

C13H19N3O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

To a solution of 70.0 mg (0.258 mmol) of tert-butyl 4-(1-hydroxyl-2-oxoethyl)-2-methyl-3-oxopiperidine-1-carboxylate (Step E) in 12 mL of benzene was added hydrazine. The reaction was heated to reflux for 3.5 h and concentrated to afford the title compound. LC/MS 194 (M+1-56).

WORKUP

后处理

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 3.5 h
  3. concentrationconcentrated