HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-Methyl-5,6,7,8-tetrahydropyrido[3,4-c]pyridazine, trifluoroacetate salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 8-methyl-5,8-dihydropyrido[3,4-c]pyridazine-7(6H)-carboxylate | HCID 69192961 | — |
| Product | 8-Methyl-5,6,7,8-tetrahydropyrido[3,4-c]pyridazine, trifluoroacetate salt | HCID 131726932 | — |
Reaction Steps
To 70.0 mg (0.258 mmol) of tert-butyl 8-methyl-5,8-dihydropyrido[3,4-c]pyridazine-7(6H)-carboxylate (Step F) was added 2 mL of trifluoroacetic acid. The reaction was stirred at ambient temperature for 1 h and concentrated to afford the title compound. LC/MS: 150 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388019B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-7d58c7c2146a4fc0b34ff669ba8f5d47 |
| Source note | uspto-grants-2008_06 |