Trifluoroacetic acid → 8-Methyl-5,6,7,8-tetrahydropyrido[3,4-c]pyridazine, trifluoroacetate salt

HRID 132873Notes

Reaction equation

[CH3:1][CH:2]1[C:7]2[N:8]=[N:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[CH3:1][CH:2]1[C:7]2[N:8]=[N:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][NH:3]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 69192961tert-Butyl 8-methyl-5,8-dihydropyrido[3,4-c]pyridazine-7(6H)-carboxylate

Product 1

HCID 1317269328-Methyl-5,6,7,8-tetrahydropyrido[3,4-c]pyridazine, trifluoroacetate salt

Procedure

To 70.0 mg (0.258 mmol) of tert-butyl 8-methyl-5,8-dihydropyrido[3,4-c]pyridazine-7(6H)-carboxylate (Step F) was added 2 mL of trifluoroacetic acid. The reaction was stirred at ambient temperature for 1 h and concentrated to afford the title compound. LC/MS: 150 (M+1).

Workup

concentrationconcentrated

Sources & evidence

ORD record: ord-7d58c7c2146a4fc0b34ff669ba8f5d47
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07388019B2

Reaction notes

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