Hydrazine hydrate (1:1) → HCID 10171457, compound

HRID 133001Notes

Reaction equation

HRID 133001 reaction equation
C([O:4][CH2:5][C:6]1[C:16]2[CH:15]=[CH:14][C:13]3[CH:17]=[CH:18][CH:19]=[C:20](I)[C:12]=3[C:11](=O)[C:10]=2[CH:9]=[CH:8][CH:7]=1)(=O)C.O.[NH2:24][NH2:25]>>[N:24]1[NH:25][C:9]2[CH:8]=[CH:7][C:6]([CH2:5][OH:4])=[C:16]3[CH:15]=[CH:14][C:13]4[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=4[C:11]=1[C:10]=23

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58646845HCID 58646845, compound

Product 1

HCID 10171457HCID 10171457, compound

Procedure

The mixture of (6-iodo-5-oxo-5H-dibenzo[a,d]cyclohepten-1-yl)methyl acetate with its 4-iodo form prepared in Example 6-h was treated with hydrazine monohydrate by the procedure of Example 1-h, and purified and separated by silica gel column chromatography (ethyl acetate:hexane=3:7), to give 320 mg and 1.1 mg of the title compounds as yellow powders, respectively.

Workup

  1. custompurified
  2. customseparated by silica gel column chromatography (ethyl acetate:hexane=3:7)

Sources & evidence

ORD record
ord-87840369fe194d7987cd32dd802b27c2
Source dataset
uspto-grants-2008_06
Patent number
US07390797B2

Reaction notes

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