Phosphorus oxychloride → 3-Chloro-5-phenyl-pyridazine-4-carbonitrile

HRID 133017Notes

Reaction equation

HRID 133017 reaction equation
O=[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[N:4][NH:3]1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 597350963-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile

Product 1

HCID 597350973-Chloro-5-phenyl-pyridazine-4-carbonitrile

Conditions

Temperature
100 °C

Procedure

3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile (70 mg) was suspended in 1 mL phosphorous oxychloride and heated to 100° C. for 6 hours. The mixture was then cooled and poured onto ice. The resulting brown solid product was filtered and air dried and used in the next step without further purification.

Workup

  1. temperatureThe mixture was then cooled
  2. additionpoured onto ice
  3. filtrationThe resulting brown solid product was filtered
  4. customair dried
  5. customused in the next step without further purification

Sources & evidence

ORD record
ord-c7b74a7fb57f4a01a554a7922ae27bad
Source dataset
uspto-grants-2008_06
Patent number
US07390808B2

Reaction notes

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