Hydrochloric Acid → 8-Methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride

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Reaction Steps

To a solution of 7-N-(tert-butoxycarbonyl)-8-methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-α]pyrazine (2.40 g, 7.83 mmol) in 40 mL of methanol was added 50 mL of methanol saturated with hydrogen chloride. The reaction was stirred at ambient temperature for 1 h. Concentration in vacuo gave the title compound as an off-white solid.

Provenance & Evidence