Hydrochloric Acid → 8-Methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride

HRID 133066Notes

Reaction equation

HRID 133066 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]2[N:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[N:16]=[C:10]2[CH:9]1[CH3:21])=O)(C)(C)C.[ClH:22]>CO>[ClH:22].[CH3:21][CH:9]1[NH:8][CH2:13][CH2:12][N:11]2[N:14]=[C:15]([C:17]([F:20])([F:18])[F:19])[N:16]=[C:10]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 693627227-N-(tert-Butoxycarbonyl)-8-methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine

Product 1

HCID 1317269368-Methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 7-N-(tert-butoxycarbonyl)-8-methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-α]pyrazine (2.40 g, 7.83 mmol) in 40 mL of methanol was added 50 mL of methanol saturated with hydrogen chloride. The reaction was stirred at ambient temperature for 1 h. Concentration in vacuo gave the title compound as an off-white solid.

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-d2715db03bff437586f8e5f8c727958a
Source dataset
uspto-grants-2008_06
Patent number
US07390809B2

Reaction notes

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