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HRID133076

反应详情

EQUATION

反应方程式

HRID 133076 的结构方程式

REACTANTS

反应物

2
结构：ClCOCc1ccccc1
HCID137983

[(Chloromethoxy)methyl]benzene

C8H9ClO

结构：CC(C)(C)OC(=O)N1CCn2nc(C(F)(F)F)nc2C1
HCID53393358

tert-Butyl 2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate

C11H15F3N4O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCn2nc(C(F)(F)F)nc2C1COCc1ccccc1
HCID69362406

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2.06 g (7.06 mmol) of 7-N-(tert-butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-α]pyrazine (Example 2, Step A) and benzyl chloromethyl ether essentially following the procedure outlined in Example 2, Step B. Purification by flash chromatography (silica gel, 5 to 10% ethyl acetate/hexane gradient) gave the title compound as a white foam. LC/MS 357 (M+1-tBu).

WORKUP

后处理

  1. customPurification by flash chromatography (silica gel, 5 to 10% ethyl acetate/hexane gradient)