HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloromethyl ether → 7-N-(tert-Butoxycarbonyl)-8-[(benzyloxy)methyl]-2-(trifluoromethyl)-5,6,7,8 tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloromethyl ether | HCID 137983 | — |
| Reactant | tert-Butyl 2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate | HCID 53393358 | — |
| Product | 7-N-(tert-Butoxycarbonyl)-8-[(benzyloxy)methyl]-2-(trifluoromethyl)-5,6,7,8 tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine | HCID 69362406 | — |
Reaction Steps
The title compound was prepared from 2.06 g (7.06 mmol) of 7-N-(tert-butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-α]pyrazine (Example 2, Step A) and benzyl chloromethyl ether essentially following the procedure outlined in Example 2, Step B. Purification by flash chromatography (silica gel, 5 to 10% ethyl acetate/hexane gradient) gave the title compound as a white foam. LC/MS 357 (M+1-tBu).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390809B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-6b60715354c14ccb8631fab76761d95e |
| Source note | uspto-grants-2008_06 |