HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-[2-(Dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7-N-(tert-Butoxycarbonyl)-8-[2-(dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine | HCID 69363279 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-[2-(Dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride | HCID 131726938 | — |
Reaction Steps
7-N-(tert-butoxycarbonyl)-8-[2-(dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-α]pyrazine (630 mg, 1.67 mmol) was dissolved in 5 mL of methanol saturated with hydrogen chloride. The reaction was stirred at ambient temperature for 1 h. Concentration in vacuo gave the title compound as an off-white solid. LC/MS 278 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390809B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-1d103654d51d408b83ef623496a5b5e9 |
| Source note | uspto-grants-2008_06 |