Hydrochloric Acid → 8-[2-(Dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride

HRID 133081Notes

Reaction equation

HRID 133081 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]2[N:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[N:16]=[C:10]2[CH:9]1[CH2:21][C:22]([N:24]([CH3:26])[CH3:25])=[O:23])=O)(C)(C)C.[ClH:27]>CO>[ClH:27].[CH3:26][N:24]([CH3:25])[C:22](=[O:23])[CH2:21][CH:9]1[NH:8][CH2:13][CH2:12][N:11]2[N:14]=[C:15]([C:17]([F:18])([F:20])[F:19])[N:16]=[C:10]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 693632797-N-(tert-Butoxycarbonyl)-8-[2-(dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine

Product 1

HCID 1317269388-[2-(Dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-alpha]pyrazine, hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7-N-(tert-butoxycarbonyl)-8-[2-(dimethylamino)-2-oxoethyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-α]pyrazine (630 mg, 1.67 mmol) was dissolved in 5 mL of methanol saturated with hydrogen chloride. The reaction was stirred at ambient temperature for 1 h. Concentration in vacuo gave the title compound as an off-white solid. LC/MS 278 (M+1).

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-1d103654d51d408b83ef623496a5b5e9
Source dataset
uspto-grants-2008_06
Patent number
US07390809B2

Reaction notes

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