Hydrazine hydrate (1:1) → HCID 15255095, compound

HRID 133083Notes

Reaction equation

HRID 133083 reaction equation
Cl[C:2]1[C:3]([CH3:9])=[N:4][CH:5]=[C:6]([CH3:8])[N:7]=1.O.[NH2:11][NH2:12]>>[NH:11]([C:2]1[C:3]([CH3:9])=[N:4][CH:5]=[C:6]([CH3:8])[N:7]=1)[NH2:12]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 667713-Chloro-2,5-dimethylpyrazine

Product 1

HCID 15255095HCID 15255095, compound

Procedure

To 3-chloro-2,5-dimethylpyrazine (26.0 g, 0.182 mol) placed in a round bottom flask was added hydrazine hydrate (75 mL). The reaction mixture was refluxed for 3 h, cooled to ambient temperature, and then kept in a refrigerator for 24 h. The precipitate was collected and washed with hexanes and diethyl ether to afford the title compound as dark colored solid. The compound was used in the next step without further purification. LC/MS 138.9 (M+1); 1H-NMR (500 MHz, CDCl3): δ 2.33 (s, 3H), 2.41 (s, 3H), 4.10 (br S, 2H), 5.75 (br s, 1H), 7.70 (s, 1H).

Workup

  1. temperatureThe reaction mixture was refluxed for 3 h
  2. customThe precipitate was collected
  3. washwashed with hexanes and diethyl ether

Sources & evidence

ORD record
ord-82918d9b0e8e438f8a7428a72c50904c
Source dataset
uspto-grants-2008_06
Patent number
US07390809B2

Reaction notes

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