HCID 17979855, compound → HCID 17979842, compound

HRID 133090Notes

Reaction equation

HRID 133090 reaction equation
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:15])[CH:8]=2)[N:3]=1>[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:15])[CH:8]=2)[N:3]=1

Participants

3

Reactant 1

HCID 17979855HCID 17979855, compound2×

Product 1

HCID 17979842HCID 17979842, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

0.24 g of palladium on charcoal (10% Pd) is added to a solution of 1.32 g of 2-amino-3-nitro-6-methylquinoline (compound B2) in 100 ml of methanoltetrahydrofurane 1:1. After hydration for 1.5 h, the catalyst is filtered off and the filtrate is concentrated in vacuo. The residue is chomatographed on silica gel (dichloromethane/methanol 8:1). 1.02 g of the title compound are obtained as colourless solid.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-98416763ad9f4d41b5d80b80b07849a0
Source dataset
uspto-grants-2008_06
Patent number
US07390819B2

Reaction notes

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