HCID 17979845, compound → HCID 17979852, compound

HRID 133091Notes

Reaction equation

HRID 133091 reaction equation
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:15][CH3:16])[CH:8]=2)[N:3]=1>[Pd].CO.O1CCCC1>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:15][CH3:16])[CH:8]=2)[N:3]=1

Participants

4

Reactant 1

HCID 17979845HCID 17979845, compound2×

Product 1

HCID 17979852HCID 17979852, compoundYield 68.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

10 mg of palladium on charcoal (10% Pd) are added to a solution of 0.64 g of 2-amino-3-nitro-6-methoxyquinoline (compound B3) in 40 ml of methanol/tetrahydrofurane 1:1. After hydration for 0.5 h, the catalyst is filtered off and the filtrate is concentrated in vacuo. 0.38 g of the title compound are obtained as light yellow solid.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-ed3ef764e67743d18213599cce8be5ee
Source dataset
uspto-grants-2008_06
Patent number
US07390819B2

Reaction notes

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