反应详情

A solution of the amine (Step C, 0.41 g, 1.2 mmol), conc. HCl (0.1 mL), and dioxane (4 mL) was heated in a microwave at 200° C. for 5 min. The mixture was concentrated in vacuo to give the crude compound as a red oil. Purification by silica flash chromatography (0-25% EtOAc:hexane) gave the desired compound as a yellow oil. MS m/e 325 (M+H)+. Calc'd for C19H20N2O3-324.37.

1. concentrationThe mixture was concentrated in vacuo
2. customto give the crude compound as a red oil
3. customPurification by silica flash chromatography (0-25% EtOAc:hexane)