2-Pyrazinecarboxylic acid → 5-(2,4-Difluoro-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13313Notes

Reaction equation

HRID 13313 reaction equation
[F:1][C:2]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:12]3[CH:17]=C[CH:15]=[CH:14][N:13]=3)=[N:11][C:7]=2[CH:6]=1.[N:37]1C=CN=CC=1C(O)=O>>[F:1][C:2]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:28])=[O:29])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:12]3[CH:17]=[N:37][CH:15]=[CH:14][N:13]=3)=[N:11][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 10472-Pyrazinecarboxylic acidHCID 231452495-(2,4-Difluoro-phenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

Product 1

HCID 112835975-(2,4-Difluoro-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

Procedure

The entitled compound was obtained as a colorless solid in the same method as in Example 197 or in accordance with the method or by combining it with an ordinary method but using 4-(2,4-difluoro-phenoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 229 and pyrazine-2-carboxylic acid.

Workup

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 197 or in accordance with the method

Sources & evidence

ORD record
ord-8a66bf5572974c0a9ba28a7fada54bd9
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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