Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1331389노트

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HRID 1331389 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC1=CC(C)=[O]->[Pd]2([O]1)[O]C(C)=CC(C)=[O]->2.CS(C)=O.O=C([O-])[O-].[K+].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1>FC(F)(F)c1ccc(N2CCOCC2)cc1

참가 물질

9

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 0%

시약·촉매·용매 4

HCID 14574551HCID 14574551, 화합물시약HCID 728124,7-Diphenyl-1,10-phenanthroline촉매HCID 178427257HCID 178427257, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

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온도
30 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-d3166b1ed78e423c9d0c1a93b2504c3d
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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