反应详情

温度

57.5 °C

104.8 g of 1-(4-methylphenyl)hydrazine hydrochloride are suspended in 525 ml of isopropyl acetate, a solution of 104.8 g of potassium carbonate in 300 ml of water is added and then the mixture is stirred until the solid has disappeared. 77.4 g of acetic anhydride are added while maintaining the temperature below 20° C. and then the mixture is left stirring at 20° C. A precipitate is observed to form, which precipitate disappears when the mixture is heated at approximately 55-60° C. The organic phase is washed twice with 200 ml of water and is then cooled at 0-5° C. overnight. The product formed is recovered by filtration and is then washed twice with 100 ml of MTBE.

1. temperaturewhile maintaining the temperature below 20° C.
2. waitthe mixture is left
3. stirringstirring at 20° C
4. customto form
5. customwhich precipitate
6. washThe organic phase is washed twice with 200 ml of water
7. temperatureis then cooled at 0-5° C. overnight
8. customThe product formed
9. filtrationis recovered by filtration
10. washis then washed twice with 100 ml of MTBE