Ethanol → Ethyl 3-(bromophenyl)acetate

HRID 133183Notes

Reaction equation

HRID 133183 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH2:17](O)[CH3:18]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 74653(3-Bromophenyl)acetic acid

Product 1

HCID 11470552Ethyl 3-(bromophenyl)acetate

Procedure

5 g of 3-bromophenylacetic acid are dissolved in 80 ml of ethanol, 3 ml of concentrated H2SO4 are added and then the mixture is heated at reflux for two hours. The ethanol is evaporated, neutralization is carried out with a saturated K2CO3 solution and then extraction is carried out with AcOEt. The organic phase is dried over MgSO4. 5.2 g of the expected compound are obtained in the liquid form.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for two hours
  3. customThe ethanol is evaporated
  4. extractionextraction
  5. dry with materialThe organic phase is dried over MgSO4

Sources & evidence

ORD record
ord-f17bba4321964639960b18f87e980192
Source dataset
uspto-grants-2008_06
Patent number
US07390818B2

Reaction notes

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