2-Pyrazinecarboxylic acid → 5-(2-Chloropyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

HRID 13319Notes

Reaction equation

HRID 13319 reaction equation
[Cl:1][C:2]1[C:7]([O:8][C:9]2[C:23]([O:24][C:25]3[CH:26]=[N:27][C:28]([S:31]([CH2:34][CH3:35])(=[O:33])=[O:32])=[CH:29][CH:30]=3)=[CH:22][C:12]3[NH:13][C:14]([C:16]4[CH:21]=C[CH:19]=[CH:18][N:17]=4)=[N:15][C:11]=3[CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[N:36]1C=CN=CC=1C(O)=O>>[Cl:1][C:2]1[C:7]([O:8][C:9]2[C:23]([O:24][C:25]3[CH:26]=[N:27][C:28]([S:31]([CH2:34][CH3:35])(=[O:33])=[O:32])=[CH:29][CH:30]=3)=[CH:22][C:12]3[NH:13][C:14]([C:16]4[CH:21]=[N:36][CH:19]=[CH:18][N:17]=4)=[N:15][C:11]=3[CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 10472-Pyrazinecarboxylic acidHCID 112029605-(2-Chloropyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Product 1

HCID 113866555-(2-Chloropyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

Procedure

The entitled compound was obtained as a colorless solid in the same method as in Example 197 or in accordance with the method or by combining it with an ordinary method but using 4-(2-chloropyridin-3-yloxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 242 and pyrazine-2-carboxylic acid.

Workup

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 197 or in accordance with the method

Sources & evidence

ORD record
ord-fdb1ff8c220349cc8eb650f8e9058571
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

Loading…