反应详情

温度

-23 °C

Following General Procedure 8-L using the product from Step B, 3-amino-2,4-dioxo-1,5-bis-cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared as a white solid. Purification was by flash chromatography eluting with CH2Cl2/MeOH (98:2 gradient to 95:5, with 5% NH3 in the MeOH) followed by recrystallization from warm CH2Cl2/hexanes (1:1) to −23° C.

1. customwas prepared as a white solid
2. customPurification
3. washeluting with CH2Cl2/MeOH (98:2 gradient to 95:5
4. customwith 5% NH3 in the MeOH) followed by recrystallization