HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 133265Generated: October 25, 2026
2,3,4,5-tetrahydro-1H-1,5-benzodiazepine → HCID 22312679, compound
https://huagongshe.com/reaction/133265
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 577192 | — |
| Reactant | 3-Azido-2,4-dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 22312257 | — |
| Product | HCID 22312679 | HCID 22312679 | — |
Reaction Steps
Following General Procedure 8-L using the product from Step B, 3-amino-2,4-dioxo-1,5-bis-cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared as a white solid. Purification was by flash chromatography eluting with CH2Cl2/MeOH (98:2 gradient to 95:5, with 5% NH3 in the MeOH) followed by recrystallization from warm CH2Cl2/hexanes (1:1) to −23° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07390801B2 |
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| Source dataset | uspto-grants-2008_06 |
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| ORD ID | ord-daefbfbb18364f409a9946b7f6f61661 |
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| Source note | uspto-grants-2008_06 |
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