HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorophenylacetic acid → HCID 10223808, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| Reactant | 3-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one | HCID 2729681 | — |
| Product | HCID 10223808 | HCID 10223808 | — |
Reaction Steps
Following General Procedure A above using 3,5-difluorophenylacetic acid (Oakwood) and 3-amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one (Example 8-X), the title compound was prepared as a solid having a melting point of 236-239° C. The reaction was monitored by tlc on silica gel (Rf=0.7 in 10% methanol/dichloromethane) and purification was by silica gel chromatography using 10% methanol/dichloromethane as the eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390801B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-1cffa7923cff42bcb0ec3b0bb34e94f5 |
| Source note | uspto-grants-2008_06 |