Trifluoroacetic acid → HCID 67109992, compound

HRID 133424Notes

Reaction equation

HRID 133424 reaction equation
C([O:5][C:6](=[O:40])[CH:7]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28](=[O:39])[NH:29][C:30]3[C:31]4[CH:38]=[CH:37][CH:36]=[CH:35][C:32]=4[S:33][CH:34]=3)=[CH:23][CH:22]=2)=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH:8]([CH3:10])[CH3:9])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[S:33]1[CH:34]=[C:30]([NH:29][C:28]([O:27][C:24]2[CH:25]=[CH:26][C:21]([C:18]3[CH:17]=[CH:16][C:15]([S:12]([NH:11][CH:7]([CH:8]([CH3:9])[CH3:10])[C:6]([OH:40])=[O:5])(=[O:14])=[O:13])=[CH:20][CH:19]=3)=[CH:22][CH:23]=2)=[O:39])[C:31]2[CH:38]=[CH:37][CH:36]=[CH:35][C:32]1=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67110442HCID 67110442, compound

Product 1

HCID 67109992HCID 67109992, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[4′-(Benzo[b]thiophen-3-ylcarbamoyloxy)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid tert-butyl ester (180 mg, 0.31 mmol) was dissolved in methylene chloride under N2 atmosphere, added with TFA (2 mL) at 0° C. and stirred for 4 hrs. Solvent was evaporated and the product dried under high vacuum to give 2-[4′-(Benzo[b]thiophen-3-ylcarbamoyloxy)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid in 66% yield (108 mg).

Workup

  1. customSolvent was evaporated
  2. customthe product dried under high vacuum

Sources & evidence

ORD record
ord-e7df4221b5904baf88c57231702782d8
Source dataset
uspto-grants-2008_06
Patent number
US07390833B2

Reaction notes

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