3-(3,5-Difluorophenyl)-3-oxopropanenitrile → 3-(1(S)-(4-Chlorobenzyl)-2(S)-((1-(3,5-difluorophenyl)-2-cyanoethyl)amino)propyl)benzonitrile

HRID 133472Notes

Reaction equation

HRID 133472 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:13])[CH:12]=1)[C:5]([CH2:7][C:8]#[N:9])=O.Cl.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C@@H:23]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=2)[C@@H:24]([NH2:26])[CH3:25])=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([CH2:22][C@@H:23]([C:27]2[CH:28]=[C:29]([CH:30]=[CH:31][CH:32]=2)[C:33]#[N:34])[C@@H:24]([NH:26][CH:5]([C:4]2[CH:3]=[C:2]([F:1])[CH:12]=[C:11]([F:13])[CH:10]=2)[CH2:7][C:8]#[N:9])[CH3:25])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 27582553-(3,5-Difluorophenyl)-3-oxopropanenitrileHCID 692680263-((2S,3S)-3-Amino-1-(4-chlorophenyl)butan-2-yl)benzonitrile hydrochloride

Product 1

HCID 692684723-(1(S)-(4-Chlorobenzyl)-2(S)-((1-(3,5-difluorophenyl)-2-cyanoethyl)amino)propyl)benzonitrile

Procedure

This compound was synthesized according to the procedure of Example 33 from 205 mg (1.13 mmol) of 3,5-difluorobenzoyl-acetonitrile and 300 mg (0.93 mmol) of 3-(4-chlorophenyl)-2(S)(3-cyanophenyl)-1(S)-methyl-propylamine hydrochloride. LC-MS: m/e=450 (M+1), 452 (M+3) (3.55 min).

Workup

  1. customThis compound was synthesized
  2. customm/e=450 (M+1), 452 (M+3) (3.55 min)

Sources & evidence

ORD record
ord-f0f9ae53b02d437da9ccbafeb65972af
Source dataset
uspto-grants-2008_06
Patent number
US07390835B2

Reaction notes

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