HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,5-Difluorophenyl)-3-oxopropanenitrile → 3-(1(S)-(4-Chlorobenzyl)-2(S)-((1-(3,5-difluorophenyl)-2-cyanoethyl)amino)propyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,5-Difluorophenyl)-3-oxopropanenitrile | HCID 2758255 | — |
| Reactant | 3-((2S,3S)-3-Amino-1-(4-chlorophenyl)butan-2-yl)benzonitrile hydrochloride | HCID 69268026 | — |
| Product | 3-(1(S)-(4-Chlorobenzyl)-2(S)-((1-(3,5-difluorophenyl)-2-cyanoethyl)amino)propyl)benzonitrile | HCID 69268472 | — |
Reaction Steps
This compound was synthesized according to the procedure of Example 33 from 205 mg (1.13 mmol) of 3,5-difluorobenzoyl-acetonitrile and 300 mg (0.93 mmol) of 3-(4-chlorophenyl)-2(S)(3-cyanophenyl)-1(S)-methyl-propylamine hydrochloride. LC-MS: m/e=450 (M+1), 452 (M+3) (3.55 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390835B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-f0f9ae53b02d437da9ccbafeb65972af |
| Source note | uspto-grants-2008_06 |