反应详情

温度

50 °C

To a solution of 105 mg (1.6 mmol) of KCN in 1 mL of water, 220 mg (0.8 mmol) of 2-bromo-4′-phenylacetophenone in 3 mL of MeCN was added. The mixture was warmed in a 50° C. bath to dissolve some of the halide. After ˜20 min the solids dissolved. The reaction was stirred for 30 min, then partitioned between 1.2 N HCl and EtOAc. The organic layer was washed with brine, dried and concentrated leaving 210 mg of the title compound which was used in the next step without purification.

1. dissolutionAfter ˜20 min the solids dissolved
2. custompartitioned between 1.2 N HCl and EtOAc
3. washThe organic layer was washed with brine
4. customdried
5. concentrationconcentrated