反应详情

A mixture of (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine dihydrochloride (4.54 g, 16.0 mmol) with a 2 M solution (80 mL) of NaOH and ethyl acetate (80 mL) was stirred, and the organic layer was separated to extract the aqueous layer with ethyl acetate (80 mL×2). The organic layers were combined, dried over anhydrous sodium sulfate, then filtered and concentrated to thereby afford free (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine (3.35 g, 99%).

1. customthe organic layer was separated
2. extractionto extract the aqueous layer with ethyl acetate (80 mL×2)
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated