HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 1-(4-chlorobenzyl)-4-[N-(3,3-diphenylpropyl)aminomethyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | {[1-(4-Chlorobenzyl)piperidin-4-yl]methyl}amine | HCID 18426145 | — |
| Reactant | 3,3-Diphenylpropyl methanesulfonate | HCID 22238292 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(4-chlorobenzyl)-4-[N-(3,3-diphenylpropyl)aminomethyl]piperidine | HCID 18426152 | 54% |
Reaction Steps
4-(Aminomethyl)-1-(4-chlorobenzyl)piperidine (120 mg) was reacted with 3,3-diphenylpropyl methanesulfonate (1.0 equivalent) in the presence of NaI (2.6 equivalents) in acetonitrile at 70° C. for 16 hours. After treatment by a conventional method, the obtained crude product was purified by column chromatography (SiO2) to afford 1-(4-chlorobenzyl)-4-[N-(3,3-diphenylpropyl)aminomethyl]piperidine (118 mg, 54%). The purity was determined by RPLC/MS (98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390830B1 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-b181519db04643e99ed7661ed0e753a9 |
| Source note | uspto-grants-2008_06 |