反应详情

4-(Aminomethyl)-1-(4-chlorobenzyl)piperidine (120 mg) was reacted with 3,3-diphenylpropyl methanesulfonate (1.0 equivalent) in the presence of NaI (2.6 equivalents) in acetonitrile at 70° C. for 16 hours. After treatment by a conventional method, the obtained crude product was purified by column chromatography (SiO2) to afford 1-(4-chlorobenzyl)-4-[N-(3,3-diphenylpropyl)aminomethyl]piperidine (118 mg, 54%). The purity was determined by RPLC/MS (98%).

1. customAfter treatment by a conventional method, the obtained crude product
2. customwas purified by column chromatography (SiO2)