3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1336865노트

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HRID 1336865 반응식
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>C1CCC2=NCCCN2CC1.COc1cccc(OC)c1NC(=O)C(=O)O.CS(C)=O.O=C1[CH](=Cc2ccccc2)->[Pd]2<-[CH](=Cc3ccccc3)C(=O)[CH](=Cc3ccccc3)->[Pd](<-[CH]1=Cc1ccccc1)<-[CH](=Cc1ccccc1)C(=O)[CH]->2=Cc1ccccc1>c1ccc(C2CCN(c3cccnc3)CC2)cc1

참가 물질

9

반응물 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

생성물 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine수율 0%HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridine수율 0%

시약·촉매·용매 4

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene시약HCID 1188645032-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acid촉매HCID 178516676HCID 178516676, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

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온도
30 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-3d47d9a8bdf24e55b9b0d84ae06287cf
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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