3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1337635Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1337635
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>C1CCC2=NCCCN2CC1.CC(C)(C)c1ccc(C=[CH](c2ccc(C(C)(C)C)cc2)->[Ni](<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)cc1.COc1cccc(OC)c1NC(=O)C(=O)O.CS(C)=O>c1ccc(C2CCN(c3cccnc3)CC2)cc1

Komponenten

9

Edukt 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Produkt 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridineAusbeute 0 %HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagenzHCID 1188645032-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acidKatalysatorHCID 178440864HCID 178440864, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel5×

Reaktionsbedingungen

Temperatur
30 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-6d11bc2e86fd4706a312a9b34d55f66e
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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