6-(Ethanesulfonyl)pyridin-3-ol → 5-(2-Fluoro-6-cyano-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13377Notes

Reaction equation

HRID 13377 reaction equation
F[C:2]1[C:3]([O:20][C:21]2[C:26]([F:27])=[CH:25][CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5]([N+:17]([O-])=O)=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[N:15][CH:14]=[CH:13][N:12]=2)=O)[CH:7]=1.[CH2:30]([S:32]([C:35]1[N:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)(=[O:34])=[O:33])[CH3:31]>>[F:27][C:26]1[CH:25]=[CH:24][CH:23]=[C:22]([C:28]#[N:29])[C:21]=1[O:20][C:3]1[C:2]([O:41][C:38]2[CH:39]=[N:40][C:35]([S:32]([CH2:30][CH3:31])(=[O:34])=[O:33])=[CH:36][CH:37]=2)=[CH:7][C:6]2[NH:8][C:9]([C:11]3[CH:16]=[N:15][CH:14]=[CH:13][N:12]=3)=[N:17][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 231454076-(Ethanesulfonyl)pyridin-3-olHCID 86619213Pyrazine-2-carboxylic acid (5-fluoro-4-(2-cyano-6-fluoro-phenoxy)-2-nitro-phenyl)-amide

Product 1

HCID 113757635-(2-Fluoro-6-cyano-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

Procedure

The entitled compound was obtained as a white solid in the same method as in Example 400 (step 3) or in accordance with the method or by combining it with an ordinary method but using pyrazine-2-carboxylic acid (5-fluoro-4-(2-cyano-6-fluoro-phenoxy)-2-nitro-phenyl)-amide obtained in Example 400 (step 2) and 6-ethanesulfonyl-pyridin-3-ol.

Workup

  1. customThe entitled compound was obtained as a white solid in the same method as in Example 400 (step 3) or in accordance with the method

Sources & evidence

ORD record
ord-0100a80a06134b3d9942f4dd6a2ed9b9
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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