HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Ethanesulfonyl)pyridin-3-ol → 5-(2-Fluoro-6-cyano-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Ethanesulfonyl)pyridin-3-ol | HCID 23145407 | — |
| Reactant | Pyrazine-2-carboxylic acid (5-fluoro-4-(2-cyano-6-fluoro-phenoxy)-2-nitro-phenyl)-amide | HCID 86619213 | — |
| Product | 5-(2-Fluoro-6-cyano-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole | HCID 11375763 | — |
Reaction Steps
The entitled compound was obtained as a white solid in the same method as in Example 400 (step 3) or in accordance with the method or by combining it with an ordinary method but using pyrazine-2-carboxylic acid (5-fluoro-4-(2-cyano-6-fluoro-phenoxy)-2-nitro-phenyl)-amide obtained in Example 400 (step 2) and 6-ethanesulfonyl-pyridin-3-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728025B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-0100a80a06134b3d9942f4dd6a2ed9b9 |
| Source note | uspto-grants-2010_06 |