3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1338583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1338583
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC(=O)[O][Pd][O]C(C)=O.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CS(C)=O.N#Cc1ccc(-c2ccc(C#N)cn2)nc1>c1ccc(C2CCN(c3cccnc3)CC2)cc1

Komponenten

9

Edukt 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Produkt 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridineAusbeute 0 %HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineReagenzHCID 167845palladium(II) acetateKatalysatorHCID 110527812,2'-BIPYRIDINE-5,5'-DICARBONITRILEKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel5×

Reaktionsbedingungen

Temperatur
60 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-85da61b38ae74497a1a02476f72307d4
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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