HRID13388

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CC(=O)OC1CCN(C(C)=O)C1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(S(C)(=O)=O)cc1

HCID67482257

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCC(O)C1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(S(C)(=O)=O)cc1

HCID23145128

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

5 mg of potassium carbonate was added to a methanol (2 ml) solution of 14 mg of (1-acetyl-2-(5-(4-(methanesulfonyl)phenoxy)-2-pyridin-2-yl-1H-benzimidazol-6-yl)pyrrolidin-3-yl acetate diastereomer A obtained in Example 468, and the reaction liquid was stirred overnight at room temperature. The solvent was evaporated away, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=15/1) to obtain the entitled compound as a white solid.

WORKUP

后处理

customA obtained in Example 468
customthe reaction liquid
customThe solvent was evaporated away
customthe resulting residue was purified
customthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=15/1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ea2fd19b10cc473f81a0dc506a42929c
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07728025B2
来源说明: uspto-grants-2010_06

反应 SMILES

C(=O)([O-])[O-].[K+].[K+].C([O:10][CH:11]1[CH2:15][CH2:14][N:13]([C:16](=[O:18])[CH3:17])[CH:12]1[C:19]1[C:20]([O:34][C:35]2[CH:40]=[CH:39][C:38]([S:41]([CH3:44])(=[O:43])=[O:42])=[CH:37][CH:36]=2)=[CH:21][C:22]2[N:26]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)[NH:24][C:23]=2[CH:33]=1)(=O)C>CO>[C:16]([N:13]1[CH2:14][CH2:15][CH:11]([OH:10])[CH:12]1[C:19]1[C:20]([O:34][C:35]2[CH:36]=[CH:37][C:38]([S:41]([CH3:44])(=[O:42])=[O:43])=[CH:39][CH:40]=2)=[CH:21][C:22]2[N:26]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)[NH:24][C:23]=2[CH:33]=1)(=[O:18])[CH3:17]