N-(tert-butoxycarbonyl)glycine → Ethyl (2-(2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-carbamate

HRID 13391Notes

Reaction equation

HRID 13391 reaction equation
[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][NH:26]3)=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:32]([O:36][C:37]([NH:39][CH2:40][C:41](O)=[O:42])=[O:38])(C)(C)[CH3:33]>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][N:26]3[C:41](=[O:42])[CH2:40][NH:39][C:37](=[O:38])[O:36][CH2:32][CH3:33])=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:30][CH:31]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 231451755-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole

Product 1

HCID 86619214Ethyl (2-(2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-carbamate

Procedure

The entitled compound was obtained in the same method as in Example 171 and 181 or in accordance with the method or by combining it with an ordinary method but using 5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole obtained in Example 162 (step 7) and N-t-butoxycarbonyl-glycine.

Workup

  1. customThe entitled compound was obtained in the same method as in Example 171 and 181 or in accordance with the method

Sources & evidence

ORD record
ord-14c0c2104d9d4b868d1102d3db6bba65
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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