反应详情

40 ml of fuming nitric acid was added to 3.9 g of N-(4-(1-acetylpyrrolidin-2-yl)-3-fluorophenyl)pyrazine-2-carboxamide with cooling with ice, and the reaction liquid was stirred at room temperature for 2 hours. The reaction liquid was diluted with water with ice, made basic with aqueous saturated sodium bicarbonate, and then extracted with chloroform. The organic layer was washed with saturated saline, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol=50/1) to obtain the entitled compound as a yellow oily substance.

1. temperaturewith cooling with ice
2. customthe reaction liquid
3. customThe reaction liquid
4. extractionextracted with chloroform
5. washThe organic layer was washed with saturated saline
6. dry with materialdried with anhydrous magnesium sulfate
7. customThe solvent was evaporated away under reduced pressure
8. customthe resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol=50/1)
9. customto obtain the entitled compound as a yellow oily substance