Dichloromethane → Trifluoroacetic acid

HRID 134295Notes

Reaction equation

HRID 134295 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:23])[c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[CH2:22]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:31][CH2:32][Cl:33].[F:24][C:25]([C:26](=[O:27])[OH:28])([F:29])[F:30]>>[F:24][C:25]([C:26](=[O:27])[OH:28])([F:29])[F:30].[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:23])[c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[CH2:22]2)[CH2:12][CH2:13]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 11522569tert-Butyl 4-(1-oxoisoindolin-2-yl)piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 154319612-(Piperidin-4-yl)isoindolin-1-one

Sources & evidence

ORD record
ord-2bbffdfe4deb4ba89ab9bea8f4a3f938
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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