4-Phenylpiperidine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1345859노트

반응식

HRID 1345859 반응식
Ic1cccnc1.c1ccc(C2CCNCC2)cc1>CC(C)c1cccc(C(C)C)c1-n1cc[n+](-c2c(C(C)C)cccc2C(C)C)c1.CC1=CC(C)=[O]->[Pd]2([O]1)[O]C(C)=CC(C)=[O]->2.CS(C)=O.C[Si](C)(C)[O-].[Cl-].[Na+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

참가 물질

9

반응물 2

HCID 698734-PhenylpiperidineHCID 707143-Iodopyridine

생성물 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine수율 0%HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridine수율 0%

시약·촉매·용매 4

HCID 23672319Sodium trimethylsilanolate시약HCID 27349131,3-Bis(2,6-diisopropylphenyl)imidazolium chloride촉매HCID 178427257HCID 178427257, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

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온도
30 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-f454837b9eea4e73b2d999bb807b76a6
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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