참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | 1-Ethylpiperazine | HCID 79196 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Ethyl-4-(4-nitrophenyl)piperazine | HCID 2857549 | — |
반응 단계
To 4-fluoro-1-nitrobenzene (1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80° C. for 16 h. Concentrated the resultant mixture and partitioned between ethyl acetate and water. The organic layer was then washed with brine and dried with sodium sulfate and concentrated. Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728010B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-2510e61220fa4f0aa0020614d8a05773 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
