反应详情

温度

80 °C

To 4-fluoro-1-nitrobenzene (1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80° C. for 16 h. Concentrated the resultant mixture and partitioned between ethyl acetate and water. The organic layer was then washed with brine and dried with sodium sulfate and concentrated. Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235.

1. concentrationConcentrated the resultant mixture
2. custompartitioned between ethyl acetate and water
3. washThe organic layer was then washed with brine
4. dry with materialdried with sodium sulfate
5. concentrationconcentrated