Piperidine → HCID 73446802, compound

HRID 1348518Notes

Reaction equation

[C:1]([C:5]1[O:6][C:7]([CH3:16])=[CH:8][C:9](=[C:11]([C:14]#[N:15])[C:12]#[N:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:17][N:18]([CH3:30])[C:19]1[S:20][C:21]([CH:28]=O)=[C:22]2[O:27][CH2:26][CH2:25][O:24][C:23]=12.N1CCCCC1>C(O)C>[C:1]([C:5]1[O:6][C:7]([CH:16]=[CH:28][C:21]2[S:20][C:19]([N:18]([CH3:17])[CH3:30])=[C:23]3[C:22]=2[O:27][CH2:26][CH2:25][O:24]3)=[CH:8][C:9](=[C:11]([C:14]#[N:15])[C:12]#[N:13])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Conditions

Temperature: 75 °C

Procedure

As shown in the following reaction 1, 2.14 g (10 mmol) of 2-(2-tert-butyl-6-methyl-pyran-4-ylidene)-malononitrile and 2.13 g (10 mmol) of 7-dimethylamino-2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carbaldehyde were added into 100 ml of ethanol, and 0.93 g (11 mmol) of piperidine was added thereto. The reaction solution was heated at 75° C. for 10 hours. After cooling the reaction solution, the precipitated red solid was filtered, and recrystallized with ethanol to obtain 2 g of the target compound (Yield 48%).

Workup

additionwas added
temperatureAfter cooling the reaction solution
filtrationthe precipitated red solid was filtered
customrecrystallized with ethanol

Sources & evidence

ORD record: ord-8564b43dc7534184b7697101410e3e8d
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211335B2

Reaction notes

Loading…