Piperidine → HCID 73446801, compound

HRID 1348519Notes

Reaction equation

HRID 1348519 reaction equation
[C:1]([C:5]1[O:6][C:7]([CH3:16])=[CH:8][C:9](=[C:11]([C:14]#[N:15])[C:12]#[N:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:17]1([N:23]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[S:34][C:33]([CH:35]=O)=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N1CCCCC1>C(O)C>[C:1]([C:5]1[O:6][C:7]([CH:16]=[CH:35][C:33]2[S:34][C:30]([C:27]3[CH:28]=[CH:29][C:24]([N:23]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:25][CH:26]=3)=[CH:31][CH:32]=2)=[CH:8][C:9](=[C:11]([C:14]#[N:15])[C:12]#[N:13])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 15374739(2-tert-Butyl-6-methyl-4H-pyran-4-ylidene)propanedinitrileHCID 184580105-[4-(Diphenylamino)phenyl]thiophene-2-carbaldehyde

Product 1

HCID 73446801HCID 73446801, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As shown in the following reaction 3, 0.72 g (3.37 mmol) of (2-(2-tert-butyl-6-methyl-pyran-4-ylidene)-malononitrile and 1 g (2.81 mmol) of 5-(4-diphenylamino-phenyl)-thiophene-2-carbaldehyde were added into 50 ml of ethanol, and 0.28 g (3.37 mmol) of piperidine was added thereto. The reaction solution was heated for 24 hours while refluxing. After cooling the reaction solution, the precipitated red solid was filtered, and recrystallized with ethanol to obtain 0.79 g of the target compound (Yield 50%).

Workup

  1. additionwas added
  2. temperatureThe reaction solution was heated for 24 hours
  3. temperaturewhile refluxing
  4. temperatureAfter cooling the reaction solution
  5. filtrationthe precipitated red solid was filtered
  6. customrecrystallized with ethanol

Sources & evidence

ORD record
ord-dd590dc6069b484bbd50972ff09490a8
Source dataset
uspto-grants-2007_05
Patent number
US07211335B2

Reaction notes

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