Piperidine → HCID 73446796, compound

HRID 1348521Notes

Reaction equation

HRID 1348521 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:5][C:6](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[CH:7]=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH2:31][CH:30]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:29]([C:38]2[CH:45]=[CH:44][C:41]([CH:42]=O)=[CH:40][CH:39]=2)[N:28]=1.N1CCCCC1>>[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH2:31][CH:30]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:29]([C:38]2[CH:39]=[CH:40][C:41]([CH:42]=[CH:1][C:2]3[O:3][C:4]([C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=4)=[CH:5][C:6](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[CH:7]=3)=[CH:44][CH:45]=2)[N:28]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 789785HCID 789785, compoundHCID 18458005HCID 18458005, compound

Product 1

HCID 73446796HCID 73446796, compound

Conditions

Temperature
75 °C

Procedure

As shown in the following reaction 5, 0.197 g (0.84 mmol) of 2-(2-methyl-6-phenyl-pyran-4-ylidene)-malononitrile and 0.30 g (0.84 mmol) of 4-[3-(2-methoxy-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-benzaldehyde were added into 20 ml of alcohol (ethanol), and 0.10 g (1.2 mmol) of piperidine was added thereto. The reaction solution was heated at 75° C. for 10 hours.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-118e6946cdca41aabad9ebf40142de05
Source dataset
uspto-grants-2007_05
Patent number
US07211335B2

Reaction notes

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