Piperidine → HCID 73446799, compound

HRID 1348522Notes

Reaction equation

HRID 1348522 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:5][C:6](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[CH:7]=1.[C:19]1([C:25]2[CH2:29][CH:28]([C:30]3[C:43]4[C:44]5=[C:45]6[C:40](=[CH:41][CH:42]=4)[CH:39]=[CH:38][CH:37]=[C:36]6[CH:35]=[CH:34][C:33]5=[CH:32][CH:31]=3)[N:27]([C:46]3[CH:53]=[CH:52][C:49]([CH:50]=O)=[CH:48][CH:47]=3)[N:26]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.N1CCCCC1>C(O)C>[C:13]1([C:4]2[O:3][C:2]([CH:1]=[CH:50][C:49]3[CH:48]=[CH:47][C:46]([N:27]4[CH:28]([C:30]5[C:43]6[C:44]7=[C:45]8[C:40](=[CH:41][CH:42]=6)[CH:39]=[CH:38][CH:37]=[C:36]8[CH:35]=[CH:34][C:33]7=[CH:32][CH:31]=5)[CH2:29][C:25]([C:19]5[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=5)=[N:26]4)=[CH:53][CH:52]=3)=[CH:7][C:6](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[CH:5]=2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 789785HCID 789785, compoundHCID 18458006HCID 18458006, compound

Product 1

HCID 73446799HCID 73446799, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

As shown in the following reaction 6, 0.5 g (2.13 mmol) of 2-(2-methyl-6-phenyl-pyran-4-ylidene)-malononitrile and 0.961 g (2.13 mmol) of 4-(3-phenyl-5-pyren-1-yl-4,5-dihydro-pyrazol-1-yl)-benzaldehyde were added into 50 ml of ethanol, and 0.27 g (3.2 mmol) of piperidine was added thereto. The reaction solution was heated at 75° C. for 10 hours.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-e6b817c6b8db4602be6b0061ab2dfcd2
Source dataset
uspto-grants-2007_05
Patent number
US07211335B2

Reaction notes

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