HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1348543Generated: November 1, 2026
Dimethylformamide → HCID 178517381, compound
https://huagongshe.com/reaction/1348543
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Propanedioic acid, 2-(2,4,6-trifluorophenyl)-, 1,3-diethyl ester | HCID 2782662 | — |
| Reactant | 1H-Imidazol-2-amine hydrochloride | HCID 12211238 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 178517381 | HCID 178517381 | 78.3% |
Reaction Steps
A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07211545B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-3548f248f23c401e85b4ee7b9c5386b4 |
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| Source note | uspto-grants-2007_05 |
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