反应详情

温度

100 °C

A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.

1. temperatureto cool to room temperature
2. concentrationThe separated water layer was concentrated
3. additionthe residue was diluted with water and conc. hydrochloric acid
4. additionwas added
5. temperatureunder ice-cooling
6. customThe precipitation
7. filtrationwas filtered
8. customdried