Ammonium Chloride → HCID 23018295, compound

HRID 1348544Notes

Reaction equation

HRID 1348544 reaction equation
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([Cl:11])[C:3]=1[C:12]1[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=1[F:20].[CH3:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.[Cl-].[NH4+]>C(Cl)(Cl)Cl>[CH3:21][CH:22]1[CH2:27][CH2:26][N:25]([C:2]2[N:7]3[CH:8]=[CH:9][N:10]=[C:6]3[N:5]=[C:4]([Cl:11])[C:3]=2[C:12]2[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=2[F:20])[CH2:24][CH2:23]1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 693814-MethylpiperidineHCID 230182755,7-Dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

Product 1

HCID 23018295HCID 23018295, compoundYield 80.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Under ice-cooling, 0.64 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.79 g of 4-methylpiperidine were mixed. The mixture was allowed to stand at room temperature for one hour, and chloroform and aqueous saturated ammonium chloride solution were added to the reaction mixture. The separated organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was washed with t-butyl methyl ether to give 0.62 g of 5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

Workup

  1. temperatureUnder ice-cooling
  2. washThe separated organic layer was washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. washThe residue was washed with t-butyl methyl ether

Sources & evidence

ORD record
ord-19a55d3a7d5d40f3895a55aa03dd0f25
Source dataset
uspto-grants-2007_05
Patent number
US07211545B2

Reaction notes

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