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HRID1348610

反应详情

EQUATION

反应方程式

HRID 1348610 的结构方程式

REACTANTS

反应物

3
结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CCCCCCC.CCOC(C)=O
HCID21899848

未命名化合物

结构：C[C@H]1Oc2ccc(F)cc2N(CC=O)C(=O)[C@H]1NC(=O)OC(C)(C)C
HCID86605287

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1Oc2ccc(F)cc2N(CCO)C(=O)[C@H]1NC(=O)OC(C)(C)C
HCID67077122

未命名化合物

收率 60.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

0.10 g (0.28 mmol) [(6R,7S)-2-Fluoro-6-methyl-8-oxo-9-(2-oxo-ethyl)-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-carbamic acid tert-butyl ester in 4 ml tetrahydrofurane were reduced with 0.02 g (0.34 mmol) sodium borohydride. Chromatography on silicagel with ethylacetate/heptane 8:2 yielded 0.06 g (56%) [(6R,7S)-2-fluoro-9-(2-hydroxy-ethyl)-6-methyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-carbamic acid tert-butyl ester, MS m/e (%): 377.3 (M+Na+, 86), 355.2 (M+H+, 14), 255.3 (100).